Article
Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal.
Tropical medicine & international health : TM & IH - 1 Nov 2005
Ndiaye D, Daily J P, Sarr O, Ndir O, Gaye O, Mboup S, Wirth D F
Abstract excerpt
Senegal recently (2004) switched to sulfadoxine-pyrimethamine (SP) with amodiaquine as first line therapy for malaria in response to increasing chloroquine resistance. In anticipation of emerging resistance to SP as a result of this change in drug pressure, we set out to define the baseline prevalence of SP-associated mutations in the dhfr and dhps genes in Plasmodium falciparum using geographically diverse and...
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