Article
Differences in selective pressure on dhps and dhfr drug resistant mutations in western Kenya.
Malaria journal - 22 Mar 2012
McCollum Andrea M, Schneider Kristan A, Griffing Sean M, Zhou Zhiyong, Kariuki Simon, Ter-Kuile Feiko, Shi Ya Ping, Slutsker Laurence, Lal Altaf A, Udhayakumar Venkatachalam, Escalante Ananias A
Abstract excerpt
BACKGROUND: Understanding the origin and spread of mutations associated with drug resistance, especially in the context of combination therapy, will help guide strategies to halt and prevent the emergence of resistance. Unfortunately, studies have assessed these complex processes when resistance is already highly prevalent. Even further, information on the evolutionary dynamics leading to multidrug-resistant...
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