Article
Five years of large-scale dhfr and dhps mutation surveillance following the phased implementation of artesunate plus sulfadoxine-pyrimethamine in Maputo Province, Southern Mozambique.
The American journal of tropical medicine and hygiene - 1 May 2010
Raman Jaishree, Little Francesca, Roper Cally, Kleinschmidt Immo, Cassam Yasmin, Maharaj Rajendra, Barnes Karen I
Abstract excerpt
Accumulation of mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) is strongly associated with sulfadoxine-pyrimethamine (SP) treatment failure. Routine surveillance for these resistance markers was conducted annually at 26 sentinel sites in Maputo Province, Mozambique, before and after the phased deployment of artesunate plus SP (AS-SP), with 15,758 children sampled between 2004...
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