Article
Successful translation of pharmacogenetics into the clinic: the abacavir example.
Molecular diagnosis & therapy - 1 Jan 2009
Phillips Elizabeth, Mallal Simon
Abstract excerpt
Abacavir hypersensitivity syndrome (AHS) is a potentially life-threatening illness occurring in 4-8% of those initiating the drug. Early studies identified a strong association between the MHC class I allele HLA-B*5701 and AHS. These studies suggested that HLA-B*5701 holds promise as a screening test to prevent AHS, but concern arose from HLA-B*5701-negative cases with a clinical diagnosis of AHS, and...
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