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Intron-3 Retention/Splicing Controls Neuronal Expression of Apolipoprotein E in the CNS

6 Feb 2008

Abstract excerpt

Neuronal expression of apolipoprotein (apo) E4 may contribute to the pathogenesis of Alzheimer's disease (AD). In studying how apoE expression is regulated in neurons, we identified a splicing variant of apoE mRNA with intron-3 retention (apoE-I3). ApoE-I3 mRNA was detected in neuronal cell lines and primary neurons, but not in astrocytic cell lines or primary astrocytes, from humans and mice by reverse...

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PMID: 18256266
DOI: 10.1523/jneurosci.3253-07.2008

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