Article
Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.
Neurobiology of aging - 1 Jan 2000
Roses A D, Gilbert J, Xu P T, Sullivan P, Popko B, Burkhart D S, Christian-Rothrock T, Saunders A M, Maeda N, Schmechel D E
Abstract excerpt
Apolipoprotein E polymorphic variants (ApoE-epsilon2, epsilon3, and epsilon4) are associated with the age of onset distribution and risk of Alzheimer disease. The question of whether ApoE is expressed at a comparatively low level in human neurons compared to astrocytes, or whether ApoE enters neuronal cytoplasm via altered endosomal metabolism is important to understanding potential pathogenic roles for ApoE as a...
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