Article

Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4<sup>+</sup>decline

2024-03-16

Abstract excerpt

Three quarters of new HIV-1 infections are reported to be initiated by a single genetic variant. Infections initiated by multiple variants have been linked with higher recipient set point viral loads (SpVL) and a faster rate of CD4 + T cell decline, indicative of a worse clinical prognosis if left untreated. These findings have not been universally replicated, however, and a mechanism through which multiple varian...

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Literature Corpus work: 45757e8a-0314-565b-a1ef-52d7acdf85f2
DOI: 10.1101/2024.03.14.24304300

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