Article
Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice.
The Journal of biological chemistry - 18 Apr 2008
Hu Jan C-C, Hu Yuanyuan, Smith Charles E, McKee Marc D, Wright J Timothy, Yamakoshi Yasuo, Papagerakis Petros, Hunter Graeme K, Feng Jerry Q, Yamakoshi Fumiko, Simmer James P
Abstract excerpt
Enamelin is critical for proper dental enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis imperfecta. We used gene targeting to generate a knock-in mouse carrying a null allele of enamelin (Enam) that has a lacZ reporter gene replacing the Enam translation initiation site and gene sequences through exon 7. Correct targeting of the transgene was confirmed by Southern...
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