Article
Consequences for enamel development and mineralization resulting from loss of function of ameloblastin or enamelin.
European journal of oral sciences - 1 Oct 2009
Smith Charles E, Wazen Rima, Hu Yuanyuan, Zalzal Sylvia F, Nanci Antonio, Simmer James P, Hu Jan C-C
Abstract excerpt
Although the nonamelogenin proteins, ameloblastin and enamelin, are both low-abundance and rapidly degrading components of forming enamel, they seem to serve essential developmental functions, as suggested by findings that an enamel layer fails to appear on teeth of mice genetically engineered to produce either a truncated form of ameloblastin (exons 5 and 6 deleted) or no enamelin at all (null). The purpose of...
Topics
- Ameloblasts
- Amelogenesis
- Animals
- Dental Enamel
- Dental Enamel Proteins
- Dentin
- Enamel Organ
- Exons
- Female
- Gene Deletion
- Genotype
- Heterozygote
- Homozygote
- Incisor