Article
Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI).
Human molecular genetics - 1 Mar 2005
Masuya Hiroshi, Shimizu Kunihiko, Sezutsu Hideki, Sakuraba Yoshiyuki, Nagano Junko, Shimizu Aya, Fujimoto Naomi, Kawai Akiko, Miura Ikuo, Kaneda Hideki, Kobayashi Kimio, Ishijima Junko, Maeda Takahide, Gondo Yoichi, Noda Tetsuo, Wakana Shigeharu, Shiroishi Toshihiko
Abstract excerpt
Amelogenesis imperfecta (AI) is a group of commonly inherited defects of dental enamel formation, which exhibits marked genetic and clinical heterogeneity. The genetic basis of this heterogeneity is still poorly understood. Enamelin, the affected gene product in one form of AI (AIH2), is an extracellular matrix protein that is one of the components of enamel. We isolated three ENU-induced dominant mouse...
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