Article
Amelogenin-deficient mice display an amelogenesis imperfecta phenotype.
The Journal of biological chemistry - 24 Aug 2001
Gibson C W, Yuan Z A, Hall B, Longenecker G, Chen E, Thyagarajan T, Sreenath T, Wright J T, Decker S, Piddington R, Harrison G, Kulkarni A B
Abstract excerpt
Dental enamel is the hardest tissue in the body and cannot be replaced or repaired, because the enamel secreting cells are lost at tooth eruption. X-linked amelogenesis imperfecta (MIM 301200), a phenotypically diverse hereditary disorder affecting enamel development, is caused by deletions or point mutations in the human X-chromosomal amelogenin gene. Although the precise functions of the amelogenin proteins in...
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