Article
Transgenic rescue of enamel phenotype in Ambn null mice.
Journal of dental research - 1 Dec 2010
Chun Y-H P, Lu Y, Hu Y, Krebsbach P H, Yamada Y, Hu J C-C, Simmer J P
Abstract excerpt
Ameloblastin null mice fail to make an enamel layer, but the defects could be due to an absence of functional ameloblastin or to the secretion of a potentially toxic mutant ameloblastin. We hypothesized that the enamel phenotype could be rescued by the transgenic expression of normal ameloblastin in Ambn mutant mice. We established and analyzed 5 transgenic lines that expressed ameloblastin from the amelogenin...
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