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Article

Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

Genetics - 1 Sept 1998

Gems D, Sutton A J, Sundermeyer M L, Albert P S, King K V, Edgley M L, Larsen P L, Riddle D L

Abstract excerpt

The nematode Caenorhabditis elegans responds to overcrowding and scarcity of food by arresting development as a dauer larva, a nonfeeding, long-lived, stress-resistant, alternative third-larval stage. Previous work has shown that mutations in the genes daf-2 (encoding a member of the insulin receptor family) and age-1 (encoding a PI 3-kinase) result in constitutive formation of dauer larvae (Daf-c), increased...

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PMID: 9725835
DOI: 10.1093/genetics/150.1.129
PMCID: PMC1460297

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Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.PMID 9725835Read ↗

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