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Article

Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.

The Journal of biological chemistry - 5 Feb 2010

Ishikawa Hiroyuki O, Ayukawa Tomonori, Nakayama Minoru, Higashi Shunsuke, Kamiyama Shin, Nishihara Shoko, Aoki Kazuhisa, Ishida Nobuhiro, Sanai Yutaka, Matsuno Kenji

Abstract excerpt

Notch is a transmembrane receptor that shares homology with proteins containing epidermal growth factor-like repeats and mediates the cell-cell interactions necessary for many cell fate decisions. In Drosophila, O-fucosyltransferase 1 catalyzes the O-fucosylation of these epidermal growth factor-...

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Identifiers

PMID: 19948734
DOI: 10.1074/jbc.M109.016964
PMCID: PMC2823552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19948734-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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