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Article

Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation.

Biology open - 15 Nov 2021

Shi Lin, Kong Ruiyan, Li Zhengran, Zhao Hang, Ma Rui, Bai Guang, Li Jing, Li Zhouhua

Abstract excerpt

Adult stem cells are critical for the maintenance of tissue homeostasis. However, how the proliferation and differentiation of intestinal stem cells (ISCs) are regulated remains not fully understood. Here, we find a mutant, stum 9-3, affecting the proliferation and differentiation of Drosophila adult ISCs in a forward genetic screen for factors regulating the proliferation and differentiation ISCs. stum 9-3 acts...

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PMID: 34731235
DOI: 10.1242/bio.058910
PMCID: PMC8576262

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