Article
Autoantibodies to glutathione S-transferase theta 1 in patients with primary sclerosing cholangitis and other autoimmune diseases.
Journal of autoimmunity - 1 Jun 2008
Ardesjö Brita, Hansson Caisa M, Bruder Carl E G, Rorsman Fredrik, Betterle Corrado, Dumanski Jan P, Kämpe Olle, Ekwall Olov
Abstract excerpt
Primary sclerosing cholangitis (PSC) is an enigmatic disorder with a suggested autoimmune basis. A variety of autoantigens have been suggested but no specific or highly directed epitope has been identified. To address this issue, we constructed a cDNA library from normal human choledochus and screened expressing clones with serum from a patient with PSC and inflammatory bowel disease (IBD). Based on this...
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