Article
Only repeatedly elevated IgG4 levels in primary sclerosing cholangitis may distinguish a particular patient phenotype.
BMC gastroenterology - 5 Aug 2024
Kalthoff Sandra, Wolniak Caroline, Lutz Philipp, Strassburg Christian P, Langhans Bettina, Dold Leona
Abstract excerpt
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic liver disease leading to inflammation with scaring and strictures of bile ducts, which can lead to liver cirrhosis. A subtype of PSC characterized by high serum IgG4 (sIgG4) levels has been reported to be associated with poor outcomes, but the exact role and the longitudinal development of sIgG4 levels in PSC progression remains to be clarified. The...
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