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Article

Genetic variants of UDP-glucuronosyltransferase 1A genes are associated with disease presentation and outcome in primary sclerosing cholangitis.

Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2020

Weismüller Tobias J, Zhou Taotao, Kalthoff Sandra, Lenzen Henrike, Manns Michael P, Strassburg Christian P

Abstract excerpt

BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease without a curative medical therapy. The human UDP-glucuronosyltransferases 1A play a major role in the detoxification and elimination of bilirubin, bile acids and xenobiotics. Whether genetic UGT1A variants determine course and outcome of PSC has not yet been described. METHODS: A large cohort of German PSC...

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PMID: 32378294
DOI: 10.1111/liv.14487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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