Article
Glutathione S-transferase T1 genetic mismatch is a risk factor for de novo immune hepatitis in liver transplantation.
Transplantation proceedings - 1 Nov 2005
Aguilera I, Sousa J M, Gavilan F, Bernardos A, Wichmann I, Nuñez-Roldan A
Abstract excerpt
Glutathione S-transferase T1 (GSTT1) is a drug metabolizing enzyme abundantly expressed in liver and kidney cells; it is encoded by a single gene that is absent in 20% of the Caucasian population. Our group found that some liver transplantation patients developed de novo immune hepatitis (IH) and that all of them had anti-GSTT1 antibodies. The main objective of this study was to analyze the influence of a GSTT1...
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