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Article

Family history of alcoholism is associated with lower 5-HT2A receptor binding in the prefrontal cortex.

Alcoholism, clinical and experimental research - 1 Apr 2008

Underwood Mark D, Mann J John, Huang Yung-Yu, Arango Victoria

Abstract excerpt

BACKGROUND: 5-Hydroxytryptophan (5-HT(2A)) receptor involvement in alcoholism is suggested by less 5-HT(2A) binding in alcohol preferring rats, association of a 5-HT(2A) receptor gene polymorphism with alcohol dependence and reduced alcohol intake with 5-HT(2A) antagonists. We sought to determine postmortem whether 5-HT(2A) receptors are altered in the prefrontal cortex (PFC) of alcoholics. METHODS: Brain tissue...

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Source

Identifiers

PMID: 18241316
DOI: 10.1111/j.1530-0277.2007.00610.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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