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Article

Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography.

Molecular psychiatry - 1 Aug 2013

Hirvonen J, Zanotti-Fregonara P, Umhau J C, George D T, Rallis-Frutos D, Lyoo C H, Li C-T, Hines C S, Sun H, Terry G E, Morse C, Zoghbi S S, Pike V W, Innis R B, Heilig M

Abstract excerpt

Brain cannabinoid CB1 receptors contribute to alcohol-related behaviors in experimental animals, but their potential role in humans with alcohol dependence is poorly understood. We measured CB1 receptors in alcohol dependent patients in early and protracted abstinence, and in comparison with control subjects without alcohol use disorders, using positron emission tomography and [(18)F]FMPEP-d2, a radioligand for...

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Identifiers

PMID: 22776901
DOI: 10.1038/mp.2012.100
PMCID: PMC3594469

Genes

CNR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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