Article
Genetic variation in the 5-HT2A receptor and altered neocortical [3H] ketanserin binding in Alzheimer's disease.
Neuroscience letters - 8 Jun 2007
Holmes C, McCulley M, Nicoll J A R, Alder J T, Chen C P L-H, Francis P T
Abstract excerpt
A common intronic single nucleotide polymorphism (T102C) in the 5-HT2A receptor gene is associated with the development of different neuropsychiatric symptoms, including hallucinations and depressive symptoms in Alzheimer's disease (AD). Differential 5-HT2A receptor binding has also been associated with the development of these symptoms in AD. However, the relationship between 5-HT2A (T102C) genotype and 5-HT2A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.