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Article

High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors.

Archives of general psychiatry - 1 Sept 2006

Volkow Nora D, Wang Gene-Jack, Begleiter Henri, Porjesz Bernice, Fowler Joanna S, Telang Frank, Wong Christopher, Ma Yeming, Logan Jean, Goldstein Rita, Alexoff David, Thanos Peter K

Abstract excerpt

CONTEXT: Predisposition to alcoholism is likely an interaction between genetic and environmental factors that confer vulnerability and protection. Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption. OBJECTIVES: To test whether high levels of D(2) receptors may be protective against alcoholism and whether...

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Identifiers

PMID: 16953002
DOI: 10.1001/archpsyc.63.9.999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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