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Article

TGF-beta signaling and aplasia cutis congenita: proposed animal model.

Journal of the California Dental Association - 1 Dec 2007

Zehnaly Armen, Hosokawa Ryoichi, Urata Mark, Chai Yang

Abstract excerpt

TGF-beta plays a role in cell migration, proliferation, and differentiation during embryonic development. This study investigated the effect of neural crest- or mesodermspecific loss of TGF-beta type II receptor in mice. These conditional knockout mice both exhibit skin defects of the skull associated with an underlying bone defect, a phenotype consistent with the human disorder aplasia cutis congenita. The...

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PMID: 18240750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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