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Article

Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects.

Development (Cambridge, England) - 1 Nov 2003

Ito Yoshihiro, Yeo Jae Yong, Chytil Anna, Han Jun, Bringas Pablo, Nakajima Akira, Shuler Charles F, Moses Harold L, Chai Yang

Abstract excerpt

Cleft palate and skull malformations represent some of the most frequent congenital birth defects in the human population. Previous studies have shown that TGFbeta signaling regulates the fate of the medial edge epithelium during palatal fusion and postnatal cranial suture closure during skull de...

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Identifiers

PMID: 12975342
DOI: 10.1242/dev.00708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12975342-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects.PMID 12975342Read ↗

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