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Article

legless insertional mutation: morphological, molecular, and genetic characterization.

Genes & development - 1 Dec 1991

Singh G, Supp D M, Schreiner C, McNeish J, Merker H J, Copeland N G, Jenkins N A, Potter S S, Scott W

Abstract excerpt

Limb morphogenesis is an excellent model system to study pattern formation during vertebrate development. The legless (lgl) insertional mutation can serve as a tool to analyze specific events in limb development at the embryologic, genetic, and molecular levels. Hemizygous mice of this transgenic line are phenotypically normal, but homozygous mutants are inviable and exhibit limb, brain, and craniofacial...

Topics

Alleles
Animals
Chromosome Mapping
Cloning, Molecular
Electrophoresis, Gel, Pulsed-Field
Embryo, Mammalian
Hindlimb
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morphogenesis

Mutation

Polymerase Chain Reaction

Tretinoin

Source

Identifiers

PMID: 1748282
DOI: 10.1101/gad.5.12a.2245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1748282-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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