Article
Teratogenic effects of retinoic acid are modulated in mice lacking expression of epidermal growth factor and transforming growth factor-alpha.
Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2005
Abbott Barbara D, Best Deborah S, Narotsky Michael G
Abstract excerpt
BACKGROUND: Epidermal growth factor (EGF) and transforming growth factor-alpha (TGFalpha) regulate cell proliferation and differentiation in the embryo. The induction of cleft palate (CP) by all trans-retinoic acid (RA) was associated with altered expression of TGFalpha, EGF receptor, and binding of EGF. This study uses knockout (KO) mice to examine the roles of EGF and TGFalpha in teratogenic responses of...
Topics
- Abnormalities, Drug-Induced
- Animals
- Bone and Bones
- Cleft Palate
- Epidermal Growth Factor
- Female
- Fetus
- Kidney Pelvis
- Mice
- Mice, Knockout
- Phenotype
- Pregnancy
- Prenatal Injuries
- Transforming Growth Factor alpha
- Tretinoin