Article
Regenerative phenotype in mice with a point mutation in transforming growth factor beta type I receptor (TGFBR1).
Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2011
Liu Jun, Johnson Kristen, Li Jie, Piamonte Victoria, Steffy Brian M, Hsieh Mindy H, Ng Nicholas, Zhang Jay, Walker John R, Ding Sheng, Muneoka Ken, Wu Xu, Glynne Richard, Schultz Peter G
Abstract excerpt
Regeneration of peripheral differentiated tissue in mammals is rare, and regulators of this process are largely unknown. We carried out a forward genetic screen in mice using N-ethyl-N-nitrosourea mutagenesis to identify genetic mutations that affect regenerative healing in vivo. More than 400 pedigrees were screened for closure of a through-and-through punch wound in the mouse ear. This led to the identification...
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