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Article

Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.

Neuron - 8 Nov 2012

Yan Dong, Jin Yishi

Abstract excerpt

MAPKKK dual leucine zipper-bearing kinases (DLKs) are regulators of synaptic development and axon regeneration. The mechanisms underlying their activation are not fully understood. Here, we show that C. elegans DLK-1 is activated by a Ca(2+)-dependent switch from inactive heteromeric to active homomeric protein complexes. We identify a DLK-1 isoform, DLK-1S, that shares identical kinase and leucine zipper domains...

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Identifiers

PMID: 23141066
DOI: 10.1016/j.neuron.2012.08.043
PMCID: PMC3508676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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