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Article

Emerging Roles of DLK1 in the Stem Cell Niche and Cancer Stemness

4 Oct 2021

Abstract excerpt

DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane protein Delta-like homologue 1 (DLK1), a non-canonical NOTCH ligand with well-described roles during development, and tumor-supportive functions in several aggressive cancer forms. Here, we review the many functions of DLK1 as a regulator of stem cell pools and tissue differentiation in tissues such as brain, muscle, and liver....

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Identifiers

PMID: 34606325
DOI: 10.1369/00221554211048951

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