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Article

Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability.

European journal of histochemistry : EJH - 12 Jan 2023

Zhang Yunlong, He Xin, Zou Jianyu, Yang Jie, Ma Ao, Tan Minghui

Abstract excerpt

Spastin, a microtubule-severing enzyme, is known to be important for neurite outgrowth. However, the role of spastin post-translational modification, particularly its phosphorylation regulation in neuronal outgrowth, remains unclear. This study aimed to investigate the effects of eliminating spastin phosphorylation on the neurite outgrowth of rat hippocampal neurons. To accomplish this, we constructed a spastin...

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Identifiers

PMID: 36632786
DOI: 10.4081/ejh.2023.3594
PMCID: PMC10300427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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