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Article

Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.

Molecular biology of the cell - 1 Nov 2016

Rao Kavitha, Stone Michelle C, Weiner Alexis T, Gheres Kyle W, Zhou Chaoming, Deitcher David L, Levitan Edwin S, Rolls Melissa M

Abstract excerpt

Mutations in >50 genes, including spastin and atlastin, lead to hereditary spastic paraplegia (HSP). We previously demonstrated that reduction of spastin leads to a deficit in axon regeneration in a Drosophila model. Axon regeneration was similarly impaired in neurons when HSP proteins atlastin, seipin, and spichthyin were reduced. Impaired regeneration was dependent on genetic background and was observed when...

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Source

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Identifiers

PMID: 27605706
DOI: 10.1091/mbc.E16-05-0287
PMCID: PMC5170858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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