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Article

Pleiotropic effects of spastin on neurite growth depending on expression levels.

Journal of neurochemistry - 1 Mar 2009

Riano Elena, Martignoni Monica, Mancuso Giuseppe, Cartelli Daniele, Crippa Francesca, Toldo Irene, Siciliano Gabriele, Di Bella Daniela, Taroni Franco, Bassi Maria Teresa, Cappelletti Graziella, Rugarli Elena I

Abstract excerpt

Hereditary spastic paraplegia (HSP) is characterized by weakness and spasticity of the lower limbs, owing to degeneration of corticospinal axons. The most common form is due to heterozygous mutations in the SPG4 gene, encoding spastin, a microtubule (MT)-severing protein. Here, we show that neurite growth in immortalized and primary neurons responds in pleiotropic ways to changes in spastin levels. Spastin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19141076
DOI: 10.1111/j.1471-4159.2009.05875.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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