Article
The PINK1/Parkin pathway regulates mitochondrial morphology.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2008
Poole Angela C, Thomas Ruth E, Andrews Laurie A, McBride Heidi M, Whitworth Alexander J, Pallanck Leo J
Abstract excerpt
Loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) or parkin genes, which encode a mitochondrially localized serine/threonine kinase and a ubiquitin-protein ligase, respectively, result in recessive familial forms of Parkinsonism. Genetic studies in Drosophila indicate that PINK1 acts upstream of Parkin in a common pathway that influences mitochondrial integrity in a subset of tissues, including...
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