Article
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008
Yang Yufeng, Ouyang Yingshi, Yang Lichuan, Beal M Flint, McQuibban Angus, Vogel Hannes, Lu Bingwei
Abstract excerpt
Mitochondria form dynamic tubular networks that undergo frequent morphological changes through fission and fusion, the imbalance of which can affect cell survival in general and impact synaptic transmission and plasticity in neurons in particular. Some core components of the mitochondrial fission/fusion machinery, including the dynamin-like GTPases Drp1, Mitofusin, Opa1, and the Drp1-interacting protein Fis1,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.