Article
Genetic mutations and functions of PINK1.
Trends in pharmacological sciences - 1 Oct 2011
Kawajiri Sumihiro, Saiki Shinji, Sato Shigeto, Hattori Nobutaka
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease. Mutations in PINK1 (PARK6) are the second most frequent cause of autosomal recessive, young-onset PD, after parkin (PARK2). PINK1 (a kinase with an N-terminal mitochondrial targeting sequence) provides protection against mitochondrial dysfunction and regulates mitochondrial morphology via fission/fusion machinery. PINK1 also acts...
Topics
- Animals
- Humans
- Mutation
- Parkinson Disease
- Protein Kinases