Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atg1-mediated autophagy suppresses tissue degeneration inpink1/parkinmutants by promoting mitochondrial fission inDrosophila

24 Oct 2018

Abstract excerpt

Mitochondrial dysfunction is considered a hallmark of multiple neurodegenerative diseases, including Parkinson’s disease (PD). The PD familial genes pink1 and parkin function in a conserved pathway that regulates mitochondrial function, including dynamics (fusion and fission). Mammalian cell culture studies suggested that the pink1/parkin pathway promotes mitophagy (mitochondrial autophagy). Mitophagy through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30354903
DOI: 10.1091/mbc.e18-04-0243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atg1-mediated autophagy suppresses tissue degeneration inpink1/parkinmutants by promoting mitochondrial fission inDrosophilaPMID 30354903Read ↗

Reduction of Protein Translation and Activation of Autophagy Protect against PINK1 Pathogenesis in Drosophila melanogasterSemantic proximity Read ↗

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.Semantic proximity Read ↗

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.Semantic proximity Read ↗

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.Semantic proximity Read ↗

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants.Semantic proximity Read ↗

Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance.Semantic proximity Read ↗

Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1.Semantic proximity Read ↗

The PINK1/Parkin pathway regulates mitochondrial morphology.Semantic proximity Read ↗

Mitophagy and Parkinson's disease: The PINK1–parkin linkSemantic proximity Read ↗

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neuronsSemantic proximity Read ↗

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.Semantic proximity Read ↗

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.