Article

<i>Drosophila</i> phosphatidylinositol-4 kinase <i>fwd</i> promotes mitochondrial fission and can suppress <i>Pink1/parkin</i> phenotypes

2020-05-14

Abstract excerpt

Balanced mitochondrial fission and fusion play an important role in shaping and distributing mitochondria, as well as contributing to mitochondrial homeostasis and adaptation to stress. In particular, mitochondrial fission is required to facilitate degradation of damaged or dysfunctional units via mitophagy. Two Parkinson’s disease factors, PINK1 and Parkin, are considered key mediators of damage-induced mitophagy...

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Literature Corpus work: 347580b3-4481-5067-bf0e-319f2d739650
DOI: 10.1101/2020.05.13.093823

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