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Article

Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance.

Biochimica et biophysica acta - 1 Sept 2014

Buhlman Lori, Damiano Maria, Bertolin Giulia, Ferrando-Miguel Rosa, Lombès Anne, Brice Alexis, Corti Olga

Abstract excerpt

Autosomal recessive early-onset Parkinson's disease is most often caused by mutations in the genes encoding the cytosolic E3 ubiquitin ligase Parkin and the mitochondrial serine/threonine kinase PINK1. Studies in Drosophila models and mammalian cells have demonstrated that these proteins regulate various aspects of mitochondrial physiology, including organelle transport, dynamics and turnover. How PINK1 and...

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Identifiers

PMID: 24878071
DOI: 10.1016/j.bbamcr.2014.05.012

Genes

PINK1

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