Article
Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study.
Biopharmaceutics & drug disposition - 1 Sept 2012
Noubarani Maryam, Kobarfard Farzad, Motevalian Manijeh, Keyhanfar Fariborz
Abstract excerpt
Omeprazole is metabolized in the liver mainly by the polymorphic CYP2C19 enzyme. Considerable ethnic differences have been reported in the pharmacokinetics of omeprazole. The present study was conducted to evaluate the pharmacokinetic parameters of omeprazole after a single oral administration to a random Iranian population. Thirty healthy male subjects, aged 24-31 years, weighing 60-98 kg completed the study....
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