Article
Identification of a single time-point for plasma lansoprazole measurement that adequately reflects area under the concentration-time curve.
Therapeutic drug monitoring - 1 Jun 2006
Niioka Takenori, Yasui-Furukori Norio, Uno Tsukasa, Sugawara Kazunobu, Kaneko Sunao, Tateishi Tomonori
Abstract excerpt
The objective of this study was to identify a single time-point for plasma lansoprazole measurement that adequately reflects area under the plasma lansoprazole concentration-time curve (AUC) after administration of lansoprazole alone or together with coadministration with CYP mediators. A randomized double-blind placebo-controlled crossover study design in 3 phases was conducted at intervals of 2 weeks. Eighteen...
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