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Article

Enantioselective disposition of lansoprazole and rabeprazole in human plasma.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jun 2006

Miura Masatomo

Abstract excerpt

Lansoprazole is extensively metabolized by CYP2C19 and CYP3A4 in the liver, whereas rabeprazole is primarily converted non-enzymatically to rabeprazole-thioether, with only some being oxidized by CYP2C19 and CYP3A4. Lansoprazole and rabeprazole possess asymmetric sulfur in their chemical structure and have typically been used clinically as a racemic mixture. This article reviews the pharmacokinetic differences...

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Source

Identifiers

PMID: 16755125
DOI: 10.1248/yakushi.126.395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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