Article
Correlation between R/S enantiomer ratio of lansoprazole and CYP2C19 activity after single oral and enteral administration.
Chirality - 1 Jul 2010
Miura Masatomo, Motoyama Satoru, Hinai Yudai, Niioka Takenori, Hayakari Makoto, Ogawa Jun-ichi, Suzuki Toshio
Abstract excerpt
The purpose of this study was to investigate whether CYP2C19 activity can be estimated from plasma concentrations of lansoprazole enantiomers 4 h (C(4h)) after single administration by oral and enteral routes. Sixty-nine subjects, 22 homozygous extensive metabolizers (homEMs), 32 heterozygous EMs...
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