Article
Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
Human molecular genetics - 15 May 2008
Chen-Plotkin Alice S, Geser Felix, Plotkin Joshua B, Clark Chris M, Kwong Linda K, Yuan Wuxing, Grossman Murray, Van Deerlin Vivianna M, Trojanowski John Q, Lee Virginia M-Y
Abstract excerpt
Frontotemporal lobar degeneration is a fatal neurodegenerative disease that results in progressive decline in behavior, executive function and sometimes language. Disease mechanisms remain poorly understood. Recently, however, the DNA- and RNA-binding protein TDP-43 has been identified as the major protein present in the hallmark inclusion bodies of frontotemporal lobar degeneration with ubiquitinated inclusions...
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