Long Non-Coding RNA Profile in Genetic Symptomatic and Presymptomatic Frontotemporal Dementia: A GENFI Study.

doi:10.3233/JAD-240557

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Long Non-Coding RNA Profile in Genetic Symptomatic and Presymptomatic Frontotemporal Dementia: A GENFI Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Serpente Maria, Fenoglio Chiara, Arcaro Marina, Carandini Tiziana, Sacchi Luca, Pintus Manuela, Rotondo Emanuela, Borracci Vittoria, Ghezzi Laura, Bouzigues Arabella, Russell Lucy L, Foster Phoebe H, Ferry-Bolder Eve, van Swieten John C, Jiskoot Lize C, Seelaar Harro, Sánchez Valle Raquel, Laforce Robert, Graff Caroline, Vandenberghe Rik, de Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Gerhard Alexander, Levin Johannes, Sorbi Sandro, Otto Markus, Pasquier Florence, Ducharme Simon, Butler Chris R, Le Ber Isabelle, Finger Elizabeth, Tartaglia Maria Carmela, Masellis Mario, Rowe James B, Synofzik Matthis, Moreno Fermin, Borroni Barbara, Rohrer Jonathan D, Arighi Andrea, Galimberti Daniela

Abstract excerpt

Background: Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and are implicated in neurodegenerative diseases, including frontotemporal dementia (FTD). However, their expression patterns and potential as biomarkers in genetic FTD involving Chromosome 9 Open Reading Frame (C9ORF72), Microtubule Associated Protein Tau (MAPT), and Progranulin (GRN) genes are not well understood. Objective: This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged

Share to Biomarkers

Share to C9orf72 Protein

Share to Frontotemporal Dementia

Share to Mutation

Share to Progranulins

Share to RNA, Long Noncoding

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39121124
DOI: 10.3233/JAD-240557
PMCID: PMC11380264

Genes

C9ORF72
GRN
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long Non-Coding RNA Profile in Genetic Symptomatic and Presymptomatic Frontotemporal Dementia: A GENFI Study.PMID 39121124Read ↗

Circulating Non-Coding RNA Levels Are Altered in Autosomal Dominant Frontotemporal Dementia.Semantic proximity Read ↗

A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes.Semantic proximity Read ↗

A multi-omics dataset for the analysis of Frontotemporal Dementia genetic subtypesSemantic proximity Read ↗

MicroRNA signatures in genetic frontotemporal dementia and amyotrophic lateral sclerosisSemantic proximity Read ↗

Integrated multi-omics analysis reveals common and distinct dysregulated pathways for genetic subtypes of Frontotemporal DementiaSemantic proximity Read ↗

Genomic and Transcriptomic Approaches Advance the Diagnosis and Prognosis of Neurodegenerative DiseasesSemantic proximity Read ↗

Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.Semantic proximity Read ↗

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects.Semantic proximity Read ↗

Underlying genetic variation in familial frontotemporal dementia: sequencing of 198 patients.Semantic proximity Read ↗

Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI studySemantic proximity Read ↗

C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers.Semantic proximity Read ↗

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.