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Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions

23 Nov 2021

Abstract excerpt

Vast numbers of differentially expressed genes and perturbed networks have been identified in Alzheimer's disease (AD), however, neither disease nor brain region specificity of these transcriptome alterations has been explored. Using RNA-Seq data from 231 temporal cortex and 224 cerebellum samples from patients with AD and progressive supranuclear palsy (PSP), a tauopathy, we identified a striking correlation in...

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PMID: 34813500
DOI: 10.1172/jci149904

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