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Article

Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.

Acta neuropathologica - 1 Jan 2010

Chen-Plotkin Alice S, Xiao Jiping, Geser Felix, Martinez-Lage Maria, Grossman Murray, Unger Travis, Wood Elisabeth M, Van Deerlin Vivianna M, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is characterized by progressive decline in behavior, executive function, and language. Progranulin (GRN) gene mutations are pathogenic for FTLD-TDP, and GRN transcript haploinsufficiency is the proposed disease mechanism. However...

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Source

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Identifiers

PMID: 19649643
DOI: 10.1007/s00401-009-0576-2
PMCID: PMC3104467

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19649643-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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