Article
Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations.
BMC genomics - 27 Oct 2011
Kocerha Jannet, Kouri Naomi, Baker Matt, Finch NiCole, DeJesus-Hernandez Mariely, Gonzalez John, Chidamparam Kumaravel, Josephs Keith A, Boeve Bradley F, Graff-Radford Neill R, Crook Julia, Dickson Dennis W, Rademakers Rosa
Abstract excerpt
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs (miRNAs) have become a major therapeutic focus as their pervasive expression and powerful regulatory roles in disease pathogenesis become increasingly apparent. Here we examine the role of miRNAs in FTLD patients with TAR DNA-binding protein 43...
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