Article
Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations.
Brain : a journal of neurology - 29 Jul 2022
Pottier Cyril, Mateiu Ligia, Baker Matthew C, DeJesus-Hernandez Mariely, Teixeira Vicente Cristina, Finch NiCole A, Tian Shulan, van Blitterswijk Marka, Murray Melissa E, Ren Yingxue, Petrucelli Leonard, Oskarsson Björn, Biernacka Joanna M, Graff-Radford Neill R, Boeve Bradley F, Petersen Ronald C, Josephs Keith A, Asmann Yan W, Dickson Dennis W, Rademakers Rosa
Abstract excerpt
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a complex heterogeneous neurodegenerative disorder for which mechanisms are poorly understood. To explore transcriptional changes underlying FTLD-TDP, we performed RNA-sequencing on 66 genetically unexplained FTLD-TDP patients, 24 FTLD-TDP patients with GRN mutations and 24 control participants. Using principal component analysis, hierarchical...
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