Article
Recent insights into the molecular genetics of dementia.
Trends in neurosciences - 1 Aug 2009
Rademakers Rosa, Rovelet-Lecrux Anne
Abstract excerpt
Our understanding of the molecular genetic basis of two common neurodegenerative dementias, Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), has greatly advanced in recent years. Progranulin mutations were identified as a major cause of FTLD and a potential susceptibility factor for other forms of dementia. In addition, through copy-number analyses of previously identified disease genes and...
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